DOI: 10.36871 / vet.san.hyg.ecol.201802016
UDC 636.3; 546.815

Authors

E. B. MIRZOEV
Federal State Budgetary Institution "ALL-RUSSIAN RESEARCH INSTITUTE OF RADIOLOGY AND AGROECOLOGY"

Abstract

On the basis of literature and experimental data, the most informative biomarkers of exposure to lead during its chronic intake with the diet in the body of sheep were determined. The choice of biomarkers of exposure was based on the mechanism of action of lead and the patterns of its intake, distribution, accumulation and excretion from the body, as well as the specificity, sensitivity and informativeness of laboratory parameters. A comparative analysis of biomarkers of the lead effect according to the criteria of specificity, sensitivity, information content and laboriousness allows us to distinguish the following series of laboratory indicators: the activity of α-ALAD in peripheral blood> the content of metallothioneins in peripheral blood lymphocytes> the content of SH-groups in peripheral blood plasma. The above biomarkers of the effect are reversible, which somewhat reduces their information content. At the same time, of the biomarkers of exposure, the concentration of lead in peripheral blood is the highest priority. The scientific substantiation of the critical limits of lead exposure in mammals highlights the assessment of the dependence of biological effects on its concentration in peripheral blood. Therefore, the activity of β-ALAD and the concentration of metal in peripheral blood can be considered the most informative biomarkers of exposure.

Keywords

lead, biomarkers,? -ALAD, metallothioneins, SH-groups, sheep.