DOI: 10.36871 / vet.san.hyg.ecol.201804013
UDC 57.084.1
Authors
N.P. BIRYUKOVA, T.V. BAKHMUTOVA, E.V. LYSENKO, V.V. NAPALKOVA
FSBI “ALL-RUSSIAN STATE CENTER FOR QUALITY AND STANDARDIZATION OF MEDICINES FOR ANIMALS AND FEEDS”
Abstract
Helminthiasis of animals is a serious industrial problem for livestock, especially for farms with a high concentration of livestock, causing significant economic damage to livestock due to the death of animals, reduced productivity, culling of organs affected by parasites and deterioration of product quality. Chemotherapy and prevention of animal helminthiasis involves the presence of anthelmintic agents, the high efficiency and safety of which has been proven in accordance with modern requirements. For this, certain scientific studies must be carried out at various levels, the most important of which is the preclinical assessment of efficacy and safety based on international standards and ensuring a comparable quality of research results. Preclinical studies, as a rule, are carried out on adequate laboratory animals, which allows us to solve a number of important theoretical and practical issues, identify new effective and safe substances, and offer optimal clinical doses and patterns of anthelmintic drugs for veterinary use for clinical testing.
Keywords
helminthiases, preclinical studies, laboratory animals, safety assessment, general toxic properties.
