STUDY OF THE HUMORAL IMMUNE RESPONSE IN LABORATORY ANIMALS ON THE ANTIGENES OF THE ASSOCIATED VACCINE AGAINST MOUTH, CORONAVIRAL INFECTION AND CALVES ECHERICHIOSIS

DOI: 10.36871 / vet.san.hyg.ecol.201901010
UDC 619.636.615.371

Authors

L. A. MNIKOVA, N. A. SOKOLOVA, M. N. LOSCHININ, A. V. GORBATOV, T. A. ISHKOVA
"FEDERAL SCIENTIFIC CENTER - ALL-RUSSIAN RESEARCH INSTITUTE OF EXPERIMENTAL VETERINARY NAMED AFTER K.I. SKRYABIN AND Y.R. KOVALENKO OF THE RUSSIAN ACADEMY OF SCIENCES "

Abstract

An associated vaccine was developed and tested in laboratory animals against rota-, coronavirus infection, and Escherichia diarrhea of ​​newborn calves, based on the use of domestic strains of rotavirus RM, coronavirus KL-2, and a suspension of purified adhesive antigens K99, F41, Att25 obtained from epizootic E. coli strains . The prepared preparation has pronounced antigenic properties and promotes the formation of specific antibodies in the blood serum of guinea pigs, rats and rabbits.

Keywords

rotaviruses, coronaviruses, Escherichia, adhesive antigens, vaccine, guinea pigs, rats, rabbits.