DEREMINATION OF THE MAXIMUM TOLERATED DOSE OF THE PREPARATION SACHABACTISUBTIL IN MICE CD-1

DOI: 10.36871 / vet.san.hyg.ecol.202002019
UDC 619: 579

Authors

XNUMXNeustroev M.P., XNUMXMurashev A.N., XNUMXBondarenko D.A., XNUMXStepanova A.M., XNUMXTarabukina N.P. XNUMXYakut Scientific Research Institute of Agriculture, Yakutsk, Russian Federation XNUMXBranch of Shemyakin – Ovchinnikov Research Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Puschino, Russian Federation XNUMXYakut State Agricultural Academy, Yakutsk, Russian Federation

Abstract

The article determines the safety and potential toxicity of the drug Saсhabactisubtil when administered intragastrically to the mice of SD-1. Male mice of the experimental groups were intragastrically administered the drug once in various doses. In mice with type 1 diabetes, the maximum tolerated dose of the drug Saсhabactisubtil from the bacterial strains B. subtilis TNP-3 and B. subtilis TNP-5 with a single intragastric administration at a dose of 5×109 and 15×109 CFU was not achieved. Therefore, the drug does not have a potential toxic effect. The test drug Saсhabactisubtil is promising for the development of starter cultures of fermented milk products and medicines.

Keywords

probiotic Saсhabaktisubtil, mice, toxicity, weight, preclinical trials.