UDC 615.9: 615.322
doi: 10.36871/vet.san.hyg.ecol.202302018
Authors
Alexandra N. Babenko,
Olga P. Dmitrieva,
Lyubov V. Krepkova,
All-Russian Research Institute of Medicinal and Aromatic Plants
Moscow 117216, Russian Federation
Abstract
Currently, the development of new domestic medicines-hepatoprotectors for veterinary
medicine is an urgent task because liver diseases of various genesis in animals occupy a leading place in
the list of non-infectious pathologies. Of particular interest are medicinal plants and substances based on
them, which influence the main mechanisms of the development of liver diseases. Such plants include
chicory – from the aerial part of which a dry extract with a pronounced hepatoprotective effect has been
obtained and standardized at the All-Russian Research Institute of Medicinal and Aromatic Plants.
The objective of our study was to study the effect of dry extract of chicory aerial part on the reproductive
function of rats in order to preclinically assess the safety of its use during pregnancy.
The article presents the results of studying the potential embryotoxic and teratogenic effects of
extract recorded in the antenatal and postnatal periods of development of the offspring of rats receiving
the studied extract intragastrically at doses of 100 and 500 mg/kg from the 1st to the 6th and from
the 6th to the 19th days of pregnancy. When administered in both periods of pregnancy in the tested
doses, the dry extract of cichory did not cause a decrease in the body weight of pregnant women,
an increase in pre- and post-implantation mortality of embryos, did not affect the body weight and
craniocaudal size of 20-day-old rat fetuses, the rate of ossification of cartilaginous bone bookmarks,
the condition of the internal organs of embryos.
The introduction of the dry extract in the first six days of pregnancy does not have a negative
effect on the postnatal development of offspring. However, when the studied extract is administered
at the maximum tested dose from 6-19 days of pregnancy, it helps to slow down the formation of
sensory-motor reflexes in the offspring.
Taking into account the changes obtained, the administration of drugs based on the studied extract
to pregnant animals during organo- and fetogenesis should be carried out under the supervision of a
veterinarian in compliance with the therapeutic dose.
Keywords
chicory (Cichorium intybus L.) dry extract of aerial part, reproductive toxicity, antenatal and postnatal development, rats
