DOI: 10.36871/vet.zoo.bio.202004005
UDC 616.366-002-003.7
Authors
N. A. Averin
Graduate student of the Department of Physiology, Pharmacology and
Toxicology named after A. N. Golikova and I. E. Mozgova,
Moscow State Academy of Veterinary Medicine
and Biotechnology – MVA by K.I. Skryabin,
Moscow, Russian Federation
A. A. Deltsov
Doctor of Veterinary Sciences, Professor of the Department of Physiology,
Pharmacology and Toxicology named after A. N. Golikova
and I. E. Mozgova, Moscow State Academy of Veterinary
Medicine and Biotechnology – MVA by K. I. Skryabin,
Moscow, Russian Federation
Abstract
In this work, hemostatic properties of the Hemoblock preparation were studied using a model of parenchymal bleeding, in comparison with a 3% aqueous solution of hydrogen peroxide. The study was carried out on 30 white rats of both sexes weighing 180–200 g. under general anesthesia. Parenchymal bleeding was modeled by applying a wound on the left lobe of the liver with a scalpel. After the use of drugs, the wound was sutured in layers, tightly. An intradermal suture was applied to the skin. To assess the hemostatic effect, the time to stop bleeding was taken into account, as well as the presence or absence of relapse of parenchymal bleeding. As a result of studies, it was found that in animals after application of the studied drug, a complete stop of bleeding was observed after 120,7±4,3 seconds. Relapses of bleeding were absent. The wound surface was without signs of tissue damage. Stable hemostasis was achieved in 100% of cases.
Keywords
parenchymal bleeding, hemoblock, hemostatic drugs.
