DOI: 10.36871/vet.zoo.bio.202009007
UDC 575.113: 571.27: 619
Authors
E. A. Klimov
Doctor of Biological Sciences, Associate Professor,
Federal Science Center for Animal Husbandry
named after Academy Member L. K. Ernst,
Moscow region, Russian Federation
E. K. Novitskaya
Federal Science Center for Animal Husbandry
named after Academy Member L. K. Ernst,
Moscow region, Russian Federation
S. N. Koval’chuk
Candidate of Biological Sciences, Federal Science
Center for Animal Husbandry named after
Academy Member L. K. Ernst,
Moscow region, Russian Federation
Abstract
Intercellular adhesion molecule CD209 (DC-SIGN) is a membrane C-type lectin receptor expressed on the surface of dendritic cells and macrophages. CD209 plays an important role in innate immunity. Many studies have shown the possibility of interaction of the CD209 molecule with a number of dangerous pathogens of humans and animals. This review summarizes information on the structure of the CD209 gene and its product, describes the role of the CD209 protein in the immune response, in the migration of dendritic cells from the blood to the tissue, and their interaction with neutrophils. The currently known signaling pathway of activation through the CD209 inflammatory response is presented. The role of CD209 as an endocytic antigen receptor and the participation of the protein in immune evasion of pathogens are discussed. The mechanisms known to date for the development of infections caused by pathogens of various nature in animals are described.
Keywords
CD209, DC-SIGN, innate immunity, pathogens.
