DOI: 10.36871/vet.zoo.bio.202106005
UDC 636.2
Authors
Zh. Yu. Muradyan
Candidate of Biological Sciences, Assistant Professor of Department
of Diagnostics, Therapy, Obstetrics and Reproduction of Animals, Moscow State Academy of Veterinary Medicine
and Biotechnology – MVA by K. I. Skryabin,
Moscow, Russian Federation
R. V. Rogov
Candidate of Biological Sciences, Assistant Professor of Department
of Diagnostics, Therapy, Obstetrics and Reproduction of Animals,
Moscow State Academy of Veterinary Medicine
and Biotechnology – MVA by K. I. Skryabin,
Moscow, Russian Federation
N. V. Pimenov
Doctor of Biological Sciences, Professor of the Russian Academy
of Sciences, Moscow State Academy of Veterinary Medicine
and Biotechnology – MVA by K. I. Skryabin,
Moscow, Russian Federation
Abstract
The paper presents the results of studying the immunostimulating properties of chitosan in the design of a vaccine against infectious rhinotracheitis in cattle. The optimal concentration of chitosan succinate as an adjuvant of the vaccine against infectious bovine rhinotracheitis was established at 0,5%. At the same time, the optimal interval between immunizations was 21 days. The work shows that the use of chitosan succinate as an adjuvant can significantly increase the level of post-vaccination immunity by 5,33 log2 in rabbits, which indicates the high adjuvant properties of chitosan.
Keywords
infectious rhinotracheitis virus of cattle, calves, rabbits, vaccine, immune response, chitosan succinate, adjuvant.
