DOI: 10.36871/vet.zoo.bio.202107003
УДК 619:616.98:579.862.1:616-076
Authors
P. Yu. Terekhov
Applicant, Federal Scientific Center — All-Russian Research Institute
of Experimental Veterinary Medicine named after
K. I. Scryabin and Ya. R. Kovalenko of
the Russian Academy of Sciences,
Moscow, Russian Federation
A. V. Kapustin
Doctor of Biological Sciences, Associate Professor, Head of the Laboratory,
Federal Scientific Center — All-Russian Research Institute
of Experimental Veterinary Medicine named after K. I. Scryabin
and Ya. R. Kovalenko of the Russian Academy of Sciences,
Moscow, Russian Federation
A. I. Laishevtsev
Candidate of Biological Sciences, Head of the Laboratory, Federal
Scientific Center — All-Russian Research Institute of
Experimental Veterinary Medicine named after K. I. Scryabin
and Ya. R. Kovalenko of the Russian Academy of Sciences,
Moscow, Russian Federation
O. A. Verkhovskiy
Doctor of Biological Sciences, President of the Research
Institute for the Diagnosis and Prevention
of Human and Animal Diseases,
Moscow, Russian Federation
T. I. Aliper
Doctor of Biological Sciences, Chairman of the
Board of Directors LLC «Vetbiochim»,
Moscow, Russian Federation
Abstract
The production of multicomponent vaccines faces certain difficulties, since all antigens included in the composition should be of an optimal amount, not compete with each other (not cause interference) and ensure the formation of a stable and long-term immune response. However, in addition to effectiveness, it should be taken into consideration that antigen overload can have a negative effect on the safety of the drug, and, therefore, it is necessary to carefully study all possible negative reactions in naturally susceptible animals. Our work presents the results of a study of the safety of the inactivated vaccine against streptococcosis in pigs «VERRES-STREPTO» developed in the period of 2016–2020. The study was carried out on laboratory animals, as well as on piglets and sows. When using the drug according to the requirements indicated in the instructions, no local and / or systemic undesirable reactions were detected in experimental animals: anaphylaxis, depression, adynamia, fever, abortion. The formation of minor aseptic oedemas, which resolved on their own within 7–10 days, was noted at the injection site. The studies showed that the drug is safe for laboratory and naturally susceptible animals in the effective recommended and double doses. The expected efficacy of the use of this drug will significantly outweigh the potential risks of its use.
Keywords
streptococcosis, vaccine, Streptococcus suis, Streptococcus pyogenes, Streptococcus porcinus, Streptococcus dysgalactiae, harmlessness, pigs, sows.
