DOI: 10.36871/vet.zoo.bio.202107005
UDC 619: 615.91: 615.285.7
Authors
A. R. Elsavasani
Postgraduate Student of the Department of Physiology, Pharmacology
and Toxicology named after A. N. Golikov and I. E. Mozgov, Moscow State Academy of Veterinary Medicine
and Biotechnology – MVA by K. I. Skryabin,
Moscow, Russian Federation
Department of Forensic Medicine and Veterinary
Toxicology, University of Alexandria,
Alexandria, Egypt
A. A. Deltsov
Doctor of Veterinary Sciences, Professor, Moscow
State Academy of Veterinary Medicine and
Biotechnology – MVA by K.I. Skryabin,
Moscow, Russian Federation
Abstract
Thiamethoxam (TMX) is one of new class neonicotinoid insecticides currently available in the
Egyptian pesticide markets. The current study was designed to investigate the toxic effect of
TMX on reproductive system in adult male rabbits.
For this purpose, sixteen adult male Chinchilla rabbits were divided into two equal groups.
Animals in the first group were treated orally with TMX at dose of 16 mg/kg b.wt for 250 days.
The second group was served as control. Obtained results also showed that TMX treatment did not
cause significant sperm DNA fragmentation, but caused marked alteration in sperm parameters
(e.g. concentration, motility and morphology).
In conclusion, administration of TMX for 90 days in male rabbits induced a noticeable adverse
effect on the testicular function and structure.
Degeneration and necrosis of the spermatogenic cells in addition to intertubular edema and
vacuolations were the major observed histopathological lesions in the testis of intoxicated animals.
Keywords
rabbit breeding, pesticides, Thiamethoxam, insecticides, neonicotinoid, rabbits, DNA.
