Study of the acute toxicity parameters of an antiseptic agent based on silver nanoparticles

UDC 619: 615.272: 615.015.35
DOI: 10.36871/vet.zoo.bio.202112008

Authors

Svetlana V. Akulova,
Moscow State Zoological Park, Moscow, Russia
Georgiy A. Frolov,
National Research Technological University "MISiS", Moscow, Russia
Jacov N. Karasenkov,
Rosdent, Moscow, Russia
Alexander A. Deltsov,
Moscow State Academy of Veterinary Medicine and Biotechnology – MVA by K. I. Skryabin, Moscow, Russia

Abstract

This work presents the results of a study of the acute toxicity of a new antiseptic agent based on silver nanoparticles. It was found that the introduction of this agent intragastrically to laboratory animals (white outbred rats in volumes of 5, 10, 15 and 20 ml and white nonlinear mice in volumes of 0,5, 1, 1,5 and 2 ml) does not cause them a toxic effect and death. The general condition of the animals, behavior, appetite and thirst in all experimental animals corresponded to the norm throughout the observation period (14 days). As a result, it was not possible to establish the exact LD50 values, they will be much higher than the maximum doses administered by us.

Keywords

acute toxicity, antiseptic agents, silver, nanoparticles, laboratory animals.