Investigation of acute toxicity of a new antiseptic agent based on copper oxide nanoparticles

UDC 619: 615.272: 615.015.35
DOI: 10.36871/vet.zoo.bio.202202010

Authors

Svetlana V. Akulova,
Moscow State Zoological Park, Moscow, Russia
Georgiy A. Frolov,
National Research Technological University "MISiS", Moscow, Russia
Jacov N. Karasenkov,
Rosdent Medical Company, Moscow, Russia;
Alexander A. Deltsov,
Moscow State Academy of Veterinary Medicine and Biotechnology – MVA by K. I. Skryabin”, Moscow, Russia

Abstract

This article presents the results of studying the parameters of acute toxicity of a new antiseptic agent based on copper oxide nanoparticles. It is concluded that the studied agent does not have a toxic effect on laboratory animals when administered intragastrical in the indicated volumes: 5 ml, 10 ml and 15 ml to white laboratory rats and 0,5 ml, 1 ml and 1,5 ml to white laboratory mice. During the entire observation period, the experimental animals were active, consumed food and water in normal quantities.
LD50 cannot be established in this experiment, since no toxic effect was recorded in the volumes we injected, and increasing doses is impractical in this experiment. Thus, LD50 will be much more than the doses we introduce, and in accordance with the standards of GOST 12.1.007-76, the studied antiseptic can be attributed to the 4th class of danger – low-hazard substances.

Keywords

acute toxicity, antiseptic, copper oxide, metal nanoparticles, laboratory animals.