Investigation of acute toxicity parameters of an antiseptic based on titanium dioxide nanoparticles

UDC 619: 615.272: 615.015.35
DOI: 10.36871/vet.zoo.bio.202203008

Authors

Svetlana V. Akulova,
Moscow State Zoological Park, Moscow, Russian Federation
Georgiy A. Frolov,
National University of Science and Technology “MISIS”, Moscow, Russian Federation
Jacov N. Karasenkov,
Rosdent, Moscow, Russian Federation
Alexander A. Deltsov,
Moscow State Academy of Veterinary Medicine and Biotechnology – MVA by K. I. Skryabin, Moscow, Russian Federation

Abstract

The article presents the results of studying the parameters of acute toxicity of a new antiseptic agent based on titanium dioxide nanoparticles. According to the results of the experiment, it was found that after a single injection of this drug into the stomach cavity of white rats in volumes of 5, 10 and 15 ml, as well as white mice in volumes of 0,5, 1 and 1,5 ml, the condition of all experimental animals during the experiment corresponded to the norm. Since the toxic effect has not been recorded, and an increase in the administered doses in this experiment is impractical, it is not possible to establish the exact value of LD50. The studied antiseptic agent can be attributed to the 4th hazard class – low-hazard substances (GOST 12.1.007-76).

Keywords

acute toxicity, antiseptic agent, titanium dioxide, metal nanoparticles, laboratory animals