Study of acute toxicity parameters of an antiseptic based on tantalum dioxide nanoparticles

UDC 619: 615.272: 615.015.35
DOI: 10.36871/vet.zoo.bio.202206004

Authors

Svetlana V. Akulova,
Moscow State Zoological Park, Moscow, Russian Federation
Georgiy A. Frolov,
National University of Science and Technology “MISIS”, Moscow, Russian Federation
Jacov N. Karasenkov,
ROSDENT LLC, Moscow, Russian Federation
Alexander A. Deltsov,
Moscow State Academy of Veterinary Medicine and Biotechnology – MVA by K. I. Skryabin, Moscow, Russian Federation

Abstract

The article presents the results of studying the parameters of acute toxicity of a new antiseptic based on tantalum dioxide nanoparticles. As a result of the experiment, it was found that with a single intragastric administration of this agent to white rats in volumes of 5 ml, 10 ml and 15 ml, as well as to white mice in volumes of 0,5 ml, 1 ml and 1,5 ml, the condition of all experimental animals for experience was normal. Since the toxic effect was not recorded, and increasing the administered doses in this experiment is not advisable, it is not possible to establish the exact value of LD50. For this reason, the studied antiseptic agent can be attributed to the 4th hazard class - low-hazard substances (GOST 12.1.007-76).

Keywords

acute toxicity, antiseptic agent, tantalum oxide, metal nanoparticles, laboratory animals