UDC 619: 616.1-6
DOI: 10.36871/vet.zoo.bio.202208001
Authors
Victoria A. Bychkova,
Anna V. Goncharova,
Vladislav A. Kostalev,
Moscow State Academy of Veterinary Medicine and Biotechnology – MVA by K. I. Skryabin”, Moscow, Russia
Abstract
Proteinuria is the excretion of any type of protein in the urine in values exceeding the physiological norm (up to 0,010 g/l). Proteinuria is a marker and factor of kidney disease, leading to a decrease in life expectancy and quality of life in this group of patients. For the detection of abnormal urinary protein excretion, the gold standard of diagnosis is the determination of the urinary protein/creatinine ratio by a quantitative test. Semi-quantitative studies on test strips are of screening value, they are more sensitive to albumin due to the large number of free amino groups than globulins, this research method shows results at a protein concentration of more than 0,30 g/l. The etiology of proteinuria is multifactorial and the causes can be prerenal, renal and postrenal, and it is also worth considering the possibility of detecting functional proteinuria - increased physical activity, hyperthermia (fever), convulsions. Of particular clinical importance is true renal proteinuria, which may occur as a result of damage to the tubular apparatus, glomeruli and / or interstitium. Several studies have found that cats with chronic kidney disease and confirmed proteinuria have a shorter survival rate than cats with chronic kidney disease without proteinuria. Thus, detection and control of proteinuria is an important aspect in the diagnosis and management of cats with chronic kidney disease.
Keywords
proteinuria, chronic kidney disease, arterial hypertension, protein/creatinine ratio, RAAS, UPC
