UDC 619: 616.58: 636.3
DOI: 10.36871/vet.zoo.bio.202301003
Authors
Valery N. Baymatov,
Galiya R. Shakirova,
Moscow State Academy of Veterinary Medicine and Biotechnology – MVA by K. I. Skryabin”, Moscow, Russia
Abstract
In a comparative aspect, studies of experimental models of hepatosis in sheep, depending on etiological factors, were carried out. Comprehensive studies made it possible to characterize the morphofunctional state of the peripheral nervous system in sheep and the vascular endothelium. With prolonged exposure to various damaging factors, there is a gradual depletion of compensatory capabilities in the peripheral nervous system and the endothelial cover of the vessels, which leads to an increase in exudative activity, respectively, and vasoconstriction. the relaxing and constrictor functions of the endothelium are disturbed, as well as the production of anticoagulant and procoagulant substances, growth factors and their inhibitors, etc. It has been established that due to the commonality of innervation, blood circulation of the abdominal organs in pathology, a combined pathology develops, which is manifested by the corresponding syndromes. In this regard, pathogenetic mechanisms of dysfunction of myelinated and unmyelinated nerve fibers and vascular endothelium have been established. Endothelial dysfunction occurs with an imbalance in the synthesis of endothelins, bradykinin, eicosanoids, NO, inactivation of acetylcholine, catecholamines, serotonin, histamine, etc. The vascular intima ceases to perform barrier, secretory, hemostatic, vasotonic functions, reducing its role in the processes of inflammation and remodeling of the vascular wall. Trophic function disorders are manifested by morphological changes in the peripheral nervous system. In myelinated and unmyelinated nerve fibers, dystrophic processes are induced that do not bypass neurolemmocytes and connective tissue.
Keywords
sheep, endothelium, vessels, nitric oxide, endothelial dysfunction
