UDC 578.81: 579.62: 57.084.2
DOI: 10.36871/vet.zoo.bio.202306010
Authors
Alexey I. Laishevtsev,
Center for Biotechnological Processing of Food Products at the Institute of Applied
Microecology – CBO of Microecology (Evolink), Moscow, Russia; Federal Scientific Center – All-Russian Research Institute of Experimental
Veterinary Medicine named after K. I. Skryabin and Ya. R. Kovalenko of
the Russian Academy of Sciences, Moscow, Russia
Nikolay V. Pimenov,
Center for Biotechnological Processing of Food Products at the Institute of Applied
Microecology – CBO of Microecology (Evolink), Moscow, Russia; Moscow State Academy of Veterinary Medicine and Biotechnology –
MVA named after K. I. Skryabin, Moscow, Russia
Abstract
Salmonella-escherichia infections are widespread and of particular relevance in poultry farming,
are the most common causes of intestinal outbreaks in young ducks. Salmonellosis of waterfowl
causes great damage to farms and is caused mainly by Salmonella enterica var. typhimurium –
S. typhimurium.
This paper presents the results of commission studies of preventive, therapeutic efficacy, as well
as the harmlessness of a drug based on bacteriophages in an industrial duck-breeding enterprise.
The rationale for initiating trials of the combined coli-salmonella bacteriophage was the periodically
recorded cases of infectious pathology caused by enterogenic bacteria Salmonella variants S. typhimurium,
S. infantis and Escherichia coli. The scientific justification is also the experience of phage
application in other branches of poultry and livestock breeding. Preventive use of the drug based on
bacteriophages "Eshrifag" will allow to achieve protective and microbiological efficiency without the
use of antibiotics, which contributes to the development of organic poultry farming in Russia.
During the tests, three groups were formed: the 1st experimental, the 2nd experimental and
the control. Evaluation of the preventive effectiveness of the use and harmlessness of the drug was
carried out from the first days of life. In the course of the study, five exposures and five spray treatments
were carried out for 5 days. lives. The positive effect of this scheme was recorded in the
absence of cases of salmonella and coli-bacterial infections in the experimental group of poultry during
the entire observation period. The absence of isolation of pathogens of salmonellosis and colibacteriosis
is confirmed by the results of a bacteriological study of a slaughtered bird. For therapeutic
purposes, the drug was prescribed when cases of salmonellosis, colibacteriosis were detected in the
experimental group, of which three outbreaks were observed during the test period. During the use of the drug, the ability of the drug to localize the disease was established. The evaluation of the
effectiveness of the use by production indicators reflected the preventive and economic feasibility
of the phage agent "Eshrifag", its harmlessness and high medicinal efficacy for the prevention and
treatment of gastrointestinal infections of ducks caused by Salmonella spp. and Escherichia coli.
Keywords
bacteriophage, salmonellosis, colibacteriosis, prevention, ducks, vaccine trials, production efficiency