UDC 638.162: 669.018.674
DOI: 10.36871/vet.zoo.bio.202308012
Authors
Oleg I. Bashnin,
Damir I. Udavliev,
Anna A. Shustova,
Russian Biotechnological University «ROSBIOTECH», Moscow, Russia
Irina V. Kushch,
Viktoriya A. Stefanova,
The All-Russian Research Institute of Veterinary Sanitation, Hygiene and
Ecology is a branch of the Federal Scientific Center – All-Russian Research Institute
of Experimental Veterinary named after K. I. Scriabin and Ya. R. Kovalenko
of the Russian Academy of Sciences, Moscow, Russia
Anton L. Bairov,
Federal Center for Animal Health, Vladimir, Russia
Abstract
The paper presents the results of studying the toxicological properties of drugs developed at ROSBIOTEKH
and VNIIVSGE – «Tektumdez» and «Theora-Dez». The preparations are intended for
use at veterinary supervision facilities, food and processing enterprises.
It was found that the studied preparations are relatively low-toxic compositions when injected into
the stomach of laboratory mice cause toxic effects in doses from 1000 mg/kg. The LD50 for Tektumdez
was 2364,0±38,14 mg/kg and for Theora-Dez was 1755,83±62,51 mg/kg. Inhalation toxicity for the
drug «Tektumdez» by the results of 3 experiments was LD50 = 61,08+2,51 g/m3 and «Theora-Dez» by
the results of 3 experiments LD50 = 58,21±0,6884 g/m3. Also preparations «Tektumdez» and «Theora-
Dez» in the applied concentrations have a mild irritating effect in the study of the local irritant effect.
According to the tests, Tektumdez and Theora-Dez were found to have no irritating and sensitizing
effect. According to the parameters of acute toxicity, the drug belongs to the 3rd class of
moderately hazardous substances when introduced into the stomach and to the 4th class of little
hazardous substances when applied to the skin according to GOST 12.1.007-76.
Keywords
Toxicity, rabbits, guinea pigs, rats, mice, disinfection, Tektumdez, Theora-Dez, Finney, Kerber
