Lactate dehydrogenase under conditions of pharmacological blockade of the sympathetic ganglion

UDC 591.481.13: 591.41: 591.112.4
DOI: 10.36871/vet.zoo.bio.202311005

Authors

Peter L. Gorelikov,
Moscow State Academy of Veterinary Medicine and Biotechnology – MVA by K. I. Skryabin”, Moscow, Russia

Abstract

The isoenzymes activity of LDH in the cranial cervical sympathetic ganglion (SCG) of rabbits was determined by disc- electrophoresis under conditions of pharmacological ganglion blockade by subcutaneous administration of the cholinolytic dimecoline. Pharmacological blockade causes significant rearrangements of the LDH isoenzyme spectrum in SCG. There is a complete reduction of M isoforms (LDH-4 and -5), H isoforms (LDH-1 and -2) only remain. It is assumed that a decrease in the activity of all LDH isoforms during pharmacological blockade occurs by allosteric inhibition and leads to a significant restructuring of metabolism and to hypofunction of SCG.

Keywords

sympathetic ganglion, cholinolytic, pharmacological blockade, LDH.