UDC 619: 616.9
DOI: 10.36871/vet.zoo.bio.202403011
Authors
Victoriya M. Shashurina,
Igor G. Ryazanov,
Ilya N. Nikonov,
Moscow State Academy of Veterinary Medicine and Biotechnology –
MVA by K. I. Skryabin, Moscow, Russia
Abstract
Marek’s disease virus (MDV) causes a deadly lymphoproliferative disease in chickens, resulting in huge economic losses in the poultry industry. MDV causes an economically important disease in chickens, and there is no evidence of MDV infections in humans. Vaccination forms the basis of the current MD control program. MDV replicates and sheds from feather follicle epithelial cells and intermediate epidermal layers of the foot skin in cell-free form into the environment. Vaccination induces anti-MDV T cell responses, which reduce host symptoms and prolong survival, but it fails to inhibit virus replication and shedding. Failure to induce sterile immunity has led to the emergence of more virulent strain. The virus is currently being studied in more detail for the further development of new effective vaccines. Immunodiffusion test, PCR and real-time PCR are used to isolate the virus from pathologic material.
Keywords
Marek’s disease (MD), GaHV-2, GaAHV3, MeHV-1/ HVT, meq gene, real-time PCR
