DOI: 10.36871 / vet.san.hyg.ecol.201804012
UDC 546.815: 599.323.4
Authors
E. B. MIRZOEV, V. O. KOBYALKO, O. A. GUBINA, N. A. FROLOVA, Yu. N. KORNEEV
Federal State Budgetary Institution "ALL-RUSSIAN RESEARCH INSTITUTE OF RADIOLOGY AND AGROECOLOGY"
Abstract
The lead content in the liver, kidneys and spleen of male Wistar rats was studied in chronic metal intake with a diet in doses of 0,0019; 0,0023 and 0,0039 mg / kg body weight. Clinically healthy animals (120 goals., Age 3 ... 4 months) were divided into four groups of 30 goals. in each. Animals of the 1st group received the main diet and served as control. Rats of groups 2, 3, and 4 (experiment) daily for 180 days of the study with the main diet received 5 g of meat contaminated with lead in different concentrations. The lead content in meat did not exceed the permissible level (0,5 mg / kg) and amounted to 0,13, respectively; 0,16 and 0,27 mg / kg. Samples of organs and tissues were taken from five animals from each group on the 30th, 60th, 90th, 120th, 150th and 180th days of intoxication. Chronic intake of lead in the diet of male rats at doses of 0,0019; 0,0023 and 0,0039 mg / kg of body weight led to an increase in the concentration of metal in the liver, kidneys and spleen. The maximum values of the indicator were observed in animals of the 4th group, which received lead at a dose of 0,0039 mg / kg body weight. A comparative analysis of the concentration of lead in organs revealed the maximum levels of metal in the kidneys, which exceeded the standards in offal of slaughtered animals established both in the Russian Federation and in Europe. The results suggest that it is necessary to review the acceptable level of lead in meat and meat products of slaughtered animals, established in the Russian Federation (0,5 mg / kg), as well as daily intake in the human body (0,0036 mg / kg body weight), recommended by WHO .
Keywords
lead, male rats, liver, kidneys, spleen.
