DOI: 10.36871 / vet.san.hyg.ecol.201902015
UDC 619: 615
Authors
DOROZHKIN V.I.
Institute of Veterinary Sanitation, Hygiene and Ecology - BRANCH of FSBI Federal Research Center of the Russian Academy of Science and Technology
BIRYUKOVA N.P., BAKHMUTOVA T.V.
FSBI “ALL-RUSSIAN STATE CENTER FOR QUALITY AND STANDARDIZATION OF MEDICINES FOR ANIMALS AND FEEDS”
Abstract
The article provides an overview of methodological recommendations, rules and guidelines for conducting preclinical studies of the general toxic effects of pharmacological drugs based on international research requirements. The introduction into the civil circulation of new drugs for veterinary use is preceded by a set of scientific studies in order to assess their effectiveness and safety in accordance with modern requirements. In this case, it is necessary to observe a certain order of research at various levels based on international standards, the most important stage of which is to study the toxic effects of a pharmacological substance in preclinical conditions. Preclinical toxicological studies are carried out with the aim of eliminating the possible adverse effects of the use of the drug in clinical trials in animals of the target species and their subsequent use in veterinary practice.
Keywords
preclinical toxicological studies, pharmacological substances, laboratory animals, safety assessment, general toxic effect.
