UDC 619: 615.9
doi: 10.36871/vet.san.hyg.ecol.202202013
Authors
Vasily I. Dorozhkin,
Natalia S. Pavlova,
Galina I. Pavlenko,
Dmitry A. Drozdov,
All-Russian Research Institute of Veterinary Sanitation, Hygiene and Ecology –
Branch of Federal State Budget Scientific Institution «Federal Scientific Center – K.I. Skryabin, Ya.R. Kovalenko All-Russian Research Institute
of Experimental Veterinary Medicine, Russian Academy of Sciences»,
Moscow, Russian Federation
Abstract
Environmental pollution with heavy metals (HM) poses a serious threat to agriculture and human health. These toxicants are practically nondegradable, widespread and occur mainly in mixtures. One of the possible ways to reduce the negative effects of heavy metals is the use of feed additives that activate the protective mechanisms of the animal body and natural components of the feed The combination of lead and cadmium at doses of 50 and 5 mg/kg, respectively, in feed caused in white rats a decrease in body weight and behavioral parameters, the content of immunoglobulins and hemoglobin concentration in the blood, an increase in the summation-threshold index (STI), a decrease in the amount of protein in the urine and SH-groups in blood serum, a significant increase in the weight coefficients of the liver and kidneys. The use of the feed additive L-threonine in lead and cadmium intoxication increased body weight, stimulated behavioral indicators, increased the content of immunoglobulins and hemoglobin in the blood; led to the normalization of STI and the level of SH-groups. Thus, the feed additive Lthreonine is effective as a means of reducing the intoxication of animals with HM and restoring the physiological parameters of the body.
Keywords
L-threonine, cadmium, lead, feed additive, reduction of toxic effects
