INDICATORS OF TOXICITY AND SAFETY OF THE INACTIVATED VACCINE AGAINST ESCHERICHIOSIS, PSEUDOMONOSIS AND ENTEROCOCCAL INFECTION FOR USE IN PIG BREEDING

UDC 636.5.087.69
doi: 10.36871/vet.san.hyg.ecol.202202018

Authors

Aleksandr V. Skorikov,
Krasnodar Research Centre for Animal Husbandry and Veterinary Medicine, Krasnodar, Russian Federation
Elena N. Novikova,
Kuban State Agrarian University named after I. T. Trubilin, Krasnodar, Russian Federation
Vyacheslav Iv. Boev,
Moscow University of Food Production, Moscow, Russian Federation

Abstract

The conducted studies reflect the results of studying the safety of pilot batches of an inactivated vaccine against escherichiosis, pseudomonosis and enterococcal infection in piglets manufactured at the FKP «Armavir biofactory», on outbred mice, rabbits, as well as suckling pigs and pregnant sows. Studies have shown that intramuscular administration of a biological preparation at the maximum tolerated doses to laboratory and productive animals did not lead to the detection of signs of acute and chronic toxicity and the manifestation of reactogenic reactions.

Keywords

vaccine, laboratory, productive animals, infections, toxicity, reactogenicity, harmlessness