УДК 619:612.11[578.245:615.36]636.28
doi: 10.36871/vet.san.hyg.ecol.202301013
Authors
Sergey V. Shabunin,
Galina A. Vostroilova,
Vasilina A. Gritsyuk,
Dmitriy I. Shabanov,
Nina A. Khokhlova,
Anastasiya A. Korchagina,
Artem V. Nekrasov,
All-Russian Veterinary Research Institute of Pathology, Pharmacology and Therapy
(ARVRIPP&T), Voronezh 394087, Russian Federation
Abstract
The article discusses an experimental model of acute carrageenan inflammation, and the possibility of correcting this state using interferon-containing drug. For the experiment, white laboratory rats (n=24) were selected, divided into 3 groups of 8 individuals. Modeling of acute inflammation was carried out by introducing a 1% solution of carrageenan into the plantar aponeurosis. The study drug was intramuscularly administered to experimental rats in a volume of 0,1 ml/kg, while to compare the results, the rats of the comparison drug group were intramuscularly administered diclofenac at a dose of 8 mg/kg, the animals of the control group - isotonic sodium chloride solution in a volume of 0,1 ml/ kg, intramuscularly. It was found that 3 hours after the administration of carrageenan, the weight of the paws in the rats of the control group significantly exceeded the index of intact limbs of the same group by 32,7%, while in the group with the use of the studied drug, edema was expressed by 1,7 times less than in the control group. In the group that was administered diclofenac, the anti-edematous effect was by 20% higher than in the control group, and more pronounced than that of the study drug. The experiment has shown that the studied drug exhibits anti-inflammatory properties.
Keywords
recombinant interferons, anti-inflammatory effect, carrageenan, experimental model, preclinical studies
