UDC 619: 616-099
doi: 10.36871/vet.san.hyg.ecol.202303017
Authors
Georgy А. Zhorov,
Natalya A. Brichko,
Lyubov L. Zakharova,
Victor N. Obryvin,
Svetlana V. Lemiyaseva,
All-Russian Research Institute for Veterinary Sanitation, Hygiene and Ecology –
Branch of Federal Scientific Center – K.I. Skryabin, Ya.R. Kovalenko All-Russian Research
Institute of Experimental Veterinary Medicine, Russian Academy of Sciences,
Moscow 123022, Russian Federation
Abstract
The development of new drugs and feed additives to reduce the accumulation of anthropogenic
and natural toxicants (heavy metals, radionuclides, mycotoxins, pesticides, etc.) in the body
of farm animals and livestock products remains an urgent task. One of the ways to solve it is to create
multifunctional products containing ferrocyanides (hexacyanoferrates) of transition metals as active
substances. In medicine and veterinary medicine, enterosorbents based on compounds of this class are
used as independent pharmacological agents, and in the form of composite preparations, which are
obtained by fixing ferrocyanides on carrier substances of different origin and chemical composition.
To study the possibility of using certain substances as carriers in the creation of new composite preparations
and to assess their effect on the detoxification properties of ferrocyanides, the sorption efficiency
of a number of mineral and organic substances with respect to Cd and Pb was studied. It was found that
the background content of Cd and Pb in the tested substances does not exceed the maximum permissible
levels of these toxicants in feed, feed additives and veterinary preparations. Under in vitro conditions, the
biomass of the fungus Inonotus obliquus (chaga), the preparations ferrocin, bifezh and KhZh-90, zeolite
tuff shivyrtuin, smectite dioctahedral, white soot and chitosan succinate have the greatest efficiency of
Cd and Pb sorption (with respect to Cd – 50.4-89.0%, Pb – 58.3-95.1%). The combined presence of Cd
and Pb reduces the sorption capacity of most of the tested substances by 1.6-63.6%.
Keywords
sorbents, ferrocyanides, hexacinoferrates, sorption properties, toxic elements, cadmium, lead