JOINT CULTIVATION OF VACCINE CLOSTRIDIA STRAINS

DOI: 10.26155 / VET.ZOO.BIO.201904007
UDC 619: 579.852.13.083.13

Authors

F.K. PULOTOV, D.A. DEVRISHOV, Z. M. Bedoeva
MOSCOW STATE ACADEMY OF VETERINARY MEDICINE AND BIOTECHNOLOGY - MBA NAMED AFTER K. I. SKRYABIN

Abstract

The article presents the results of culturing anaerobic bacteria clostridia to produce toxins and antigenic cultures with better growth properties. The possibility of co-cultivation and use of modified culture media for the deep cultivation of clostridia strains in a bioreactor is shown. The results of studying the safety and immunogenic activity of experimental series of vaccines grown on various nutrient media in laboratory animals are also presented.

Keywords

co-cultivation of clostridia, bioreactors, culture media, vaccine, safety, immunogenicity.