DOI: 10.26155 / VET.ZOO.BIO.201905002
UDC 619
Authors
A.M. EL-SEBEY, P.N. ABRAMOV
MOSCOW STATE ACADEMY OF VETERINARY MEDICINE AND BIOTECHNOLOGY - MBA NAMED AFTER K. I. SKRYABIN
Abstract
The work was carried out in order to study the important role of clinical examination, laboratory methods and diagnostic imaging in confirming the early diagnosis of subclinical chronic hepatitis (CCH) and, therefore, in preventing the development of liver cirrhosis. A clinical study was conducted on dogs (n = 40). The first group (control) included clinically healthy animals (n = 20) and was used as a control. The second group (CCH) of dogs showed nonspecific clinical signs (anorexia, general depression, vomiting, diarrhea, painful palpation of the abdomen) and hematological changes, such as normocytic normochromic anemia, lymphocytosis, monocytosis and thrombocytopenia, as well as a significant increase in serum activity of alanine aminotransferase (A ) and aspartate aminotransferase (AST), alkaline phosphatase (AL) and gamma-glutamyl transferase (GGT), in addition to the level of total bilirubin, direct bilirubin and ammonia compared to the control group. The concentration of total protein, albumin, globulin, the ratio of albumin and globulin (A / G), glucose and urea decreased significantly compared with the control group. Urine analysis revealed the presence of crystals of calcium oxalate, ammonium biourate and uric acid, ultrasound revealed a diffuse and focal increase in hepatic echogenicity. Using a cytological study, the peripheral cytoplasmic rarefaction of hepatocytes was determined. However, during histological examination, proliferation of fibrous tissue and infiltration of mononuclear cells in the liver parenchyma were noted. The conducted studies have confirmed the presence of subclinical chronic hepatitis in animals of the CCH group.
Keywords
hepatitis, hematology, biochemistry, urine analysis, ultrasound, cytology and histopathology.
