DOI: 10.36871/vet.zoo.bio.202105006
UDC 619: 615.3
Authors
M. I. Burmistrova
Applicant for the Department of Physiology, Pharmacology
and Toxicology named after A. N. Golikov and I. E. Mozgov,
Moscow State Academy of Veterinary Medicine
and Biotechnology – MVA by K. I. Skryabin,
Moscow, Russian Federation
S. V. Engashev
Doctor of Veterinary Sciences, Academician of the Russian Academy
of Sciences, Professor of the Department of Parasitology
and Veterinary and Sanitary Expertise,
Moscow State Academy of Veterinary Medicine
and Biotechnology – MVA by K. I. Skryabin,
Moscow, Russian Federation
A. A. Deltsov
Doctor of Veterinary Sciences, Associate Professor, Head of the Department
of Physiology, Pharmacology and Toxicology named after A. N. Golikova
and I. E. Mozgov, Moscow State Academy of Veterinary Medicine
and Biotechnology – MVA by K. I. Skryabin,
Moscow, Russian Federation
E. S. Engasheva
Candidate of Veterinary Sciences, Researcher, All-Russian Research
Institute of Veterinary Sanitation, Hygiene and Ecology – a Branch
of the Federal Scientific Center – All-Russian Research Institute
of Experimental Veterinary Medicine by K. I. Skryabin
and Ya. R. Kovalenko Russian Academy of Sciences,
Moscow, Russian Federation
Abstract
Cumulative properties (accumulation of a substance or its effect upon repeated administration in
equal doses) is determined on the basis of a quantitative indicator – the cumulation coefficient.
Before carrying out chronic toxicological experiments, it is necessary to determine the cumulation
index of the pharmacological substance – the ratio of LD50 with a single administration to LD50 with
multiple administration.
According to the Lim method, the cumulative properties of the drug Delcid 7,5® were studied,
the cumulation coefficient of the drug was Kkum = 1,09. In accordance with the classification of
chemicals, including pesticides by L.I. For a bear, the drug belongs to a group of substances with
pronounced cumulation.
Keywords
Delcid 7,5, pyrethroid deltamethrin, insectoacaricide, toxicity.
