DOI: 10.36871/vet.zoo.bio.202106006
UDC 619
Authors
A. N. Shkatova
Postgraduate Student of the Department of Immunology and
Biotechnology, Moscow State Academy of Veterinary Medicine
and Biotechnology – MVA by K.I. Skryabin,
Moscow, Russian Federation
D. A. Devrishov
Doctor of Biological Sciences, Professor, Corresponding Member
of the Russian Academy of Sciences, Head of the Department
of Immunology and Biotechnology,
Moscow State Academy of Veterinary Medicine
and Biotechnology – MVA by K.I. Skryabin,
Moscow, Russian Federation
O. B. Litvinov
Doctor of Veterinary Sciences, Professor, Department
of Immunology and Biotechnology, Moscow State
Academy of Veterinarian Medicine and
Biotechnology – MVA by K. I. Skryabin,
Moscow, Russian Federation
V. E. Brylina
Candidate of Veterinary Sciences, Associate Professor
of the Department of Immunology and Biotechnology,
Moscow State Academy of Veterinary Medicine
and Biotechnology – MVA by K.I. Skryabin,
Moscow, Russian Federation
Abstract
In a subchronic experiment with intramuscular injection in rats, it was found that a dose of 70,7 mg/kg is toxic, and doses of 10 and 35,4 mg/kg are inactive (safe). It was noted that the 17,2 day administration of the drug «Ketoprofen 14%» in a dose 10 mg/kg caused a decrease in the body weight of experimental animals, contributed to the development of hepatotoxic action, a change in the mass coefficients of internal organs. The above effects were reversible 70,7 days after discontinuation of the study drug.
Keywords
ketoprofen, subchronic toxicity, intramuscular injection, rats, LD50 , body weight, clinical indicators, biochemistry indicators.
