UDC 619: 616.98: 578.834: 115
DOI: 10.36871/vet.zoo.bio.202211005
Authors
Vasily P. Ivanyuk,
Oleg Yu. Meshcheryakov,
Gulnora Sh. Navruzshoeva,
Moscow State Academy of Veterinary Medicine
and Biotechnology – MVA by K. I. Skryabin,
Moscow, Russian Federation
Abstract
Leptospirosis is a natural focal infectious disease of domestic and wild animals of many species,
including humans. This disease in the conditions of the Bezhitsky veterinary hospital in Bryansk
tends to increase over the past three years. In 2019, 9 dogs suffering from leptospirosis were
registered, in 2020 – 12, in 2021 – 16 dogs.
The change in biochemical parameters with varying degrees of severity of the course of leptospirosis
was profound. The total protein content throughout the experiment was lower than the control
by 29,6, 25,4 and 32,7 %, respectively. Indicators of nitrogenous products in the blood – urea and
creatinine had a tendency to increase. Glucose on days 1-9-18 of the experiment was lower than in
control individuals in 1,6–2,9–2,4 three times. Cholesterol increased throughout the study, but the
peak of its rise was observed on day 9 – 39,2 %. The highest concentration of bilirubin was 4,4 times
at the initial stage. Calcium and phosphorus tended to decrease in comparison with the control only
at the end of the experiment by 41,4 and 46,1 %, respectively. The indicators of enzyme metabolism
were strained and were high compared to the control analogues. On days 1–9–18 of the study, the
ALT and AST levels were higher, respectively, in 2,0–2,1–2,2 and 2,6–2,7–2,8 three times. The content
of alkaline phosphatase was the most significant on the 18th day of the experiment.
The most effective result from complex treatment was obtained in the experimental group, where
the chemotherapeutic agent enrofloxacin, hepatotropic – heptral, hormonal – dexamethasone and
others were used. In the control group, where traditional therapy was used, the clinical status of the
animals was normalized on day 17, in the experimental group – on day 12.
Keywords
dogs, nosological form, leptospirosis, blood, biochemical parameters, complex therapy