UDC 619: 616.98: 578.834: 115
DOI: 10.36871/vet.zoo.bio.202211005

Authors

Vasily P. Ivanyuk,
Oleg Yu. Meshcheryakov,
Gulnora Sh. Navruzshoeva,
Moscow State Academy of Veterinary Medicine and Biotechnology – MVA by K. I. Skryabin, Moscow, Russian Federation

Abstract

Leptospirosis is a natural focal infectious disease of domestic and wild animals of many species, including humans. This disease in the conditions of the Bezhitsky veterinary hospital in Bryansk tends to increase over the past three years. In 2019, 9 dogs suffering from leptospirosis were registered, in 2020 – 12, in 2021 – 16 dogs.
The change in biochemical parameters with varying degrees of severity of the course of leptospirosis was profound. The total protein content throughout the experiment was lower than the control by 29,6, 25,4 and 32,7 %, respectively. Indicators of nitrogenous products in the blood – urea and creatinine had a tendency to increase. Glucose on days 1-9-18 of the experiment was lower than in control individuals in 1,6–2,9–2,4 three times. Cholesterol increased throughout the study, but the peak of its rise was observed on day 9 – 39,2 %. The highest concentration of bilirubin was 4,4 times at the initial stage. Calcium and phosphorus tended to decrease in comparison with the control only at the end of the experiment by 41,4 and 46,1 %, respectively. The indicators of enzyme metabolism were strained and were high compared to the control analogues. On days 1–9–18 of the study, the ALT and AST levels were higher, respectively, in 2,0–2,1–2,2 and 2,6–2,7–2,8 three times. The content of alkaline phosphatase was the most significant on the 18th day of the experiment.
The most effective result from complex treatment was obtained in the experimental group, where the chemotherapeutic agent enrofloxacin, hepatotropic – heptral, hormonal – dexamethasone and others were used. In the control group, where traditional therapy was used, the clinical status of the animals was normalized on day 17, in the experimental group – on day 12.

Keywords

dogs, nosological form, leptospirosis, blood, biochemical parameters, complex therapy