UDC 619: 616.98
DOI: 10.36871/vet.zoo.bio.202308007
Authors
Andrey G. Koshchaev,
Nino N. Gugushvili,
Aleksey A. Troshin,
Kuban State Agrarian University named after I. T. Trubilin,
Krasnodar, Russia
Abstract
Escherichiosis at a group of infections, which are characterized by a wide prevalence in the conditions of industrial animal husbandry. In the structure of infectious diseases of cattle in the Kuban, escherichiosis ranges from 4,76 to 9,03 % of the total. It was found that the cause of the disease is pathogenic strains of E. coli K99, with virulence of the minimum lethal dose MLD50 – 6,5×108 microbial cells for mice with intraperitoneal infection. A predisposing factor in the pathogenesis of calf coli was immunobiological deficiency associated with a lack of vitamin A and glucose. The use of the dosage form of the cephalosporin antibiotic cefkinome sulfate cefkin 45 in case of escherichiosis, including in combination with the drug retinol palmitate in propylene glycol, did not inhibit the cellular link of immunity in calves, contributed to an increase in the phagocytic number by 46,8 %, the number of γ-globulins by 16,8 %. In comparison with fluoroquinolone and the drug of the tetracycline group, it made it possible to reduce the period of clinical recovery of calves with escherichiosis by 1–2 days, while reducing the loss of weight gain by an average of 23,5 %.
Keywords
escherichiosis, virulence, calves, immunity, treatment, cefkinom
